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Retroperitoneal Fibrosis, Mitral Regurgitation, Edema, and Hemolytic Anemia

Peter H. Slugg, MD; Robert S. Kunkel, MD

JAMA. 1970;213(2):297-298.

Abstract
Methysergide has been implicated as a causative agent of inflammatory fibrotic processes. A positive direct Coombs' test, associated with a hemolytic anemia, was obtained from a patient who had been receiving methysergide and who also had retroperitoneal fibrosis and mitral insufficiency. It is likely that the valvular disease, retroperitoneal fibrosis, and hemolytic anemia are all part of an autoimmune process induced by methysergide.

Author Affiliations
From the Department of Internal Medicine, The Cleveland (Ohio) Clinic Foundation. Dr. Slugg is a fellow of the Department of Internal Medicine.

Footnotes
Reprint requests to 2020 E 93rd St, Cleveland 44106 (Dr. Kunkel).

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