 |
|
Griseofulvin-Phenobarbital Interaction in Man
Sidney Riegelman, PhD;
William L. Epstein, MD
JAMA. 1970;213(3):426-431.
Abstract
The concept that phenobarbital sodium interferes with metabolism of griseofulvin due to its ability to induce liver enzymes that increase drug metabolism was tested by a random crossover study of six healthy male volunteers who received griseofulvin orally and intravenously, both with and without phenobarbital. The elimination kinetics of griseofulvin for a given subject were identical with or without the administration of phenobarbital; thus, no evidence for enzyme induction was observed. However, the amount of orally administered griseofulvin absorbed with phenobarbital administration fell well below that seen when no phenobarbital was given, implying that phenobarbital reduces absorption of the drug.
Author Affiliations
From the Department of Pharmacy and Pharmaceutical Chemistry, University of California School of Pharmacy (Drs. Riegelman and Rowland); and the Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco (Dr. Epstein).
Footnotes
Reprint requests to School of Pharmacy, University of California, San Francisco 94122 (Dr. Riegelman).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Cytokinesis-block micronucleus assay in primary human liver fibroblasts exposed to griseofulvin and mitomycin C
Nesti et al.
Mutagenesis 2000;15:143-147.
ABSTRACT
| FULL TEXT
Adverse Drug Interactions Clinically Important for the Dermatologist
Andersen and Feingold
Arch Dermatol 1995;131:468-473.
ABSTRACT
Gastrointestinal Absorption of Griseofulvin From Corn Oil-in-Water Emulsions: Effect of Amount of Corn Oil Ingested in Man
Bates et al.
Arch Dermatol 1977;113:302-306.
ABSTRACT
Pharmacokinetic Drug Interactions: Sedative, Hypnotic, and Antianxiety Agents
Kosman
JAMA 1974;229:1485-1488.
ABSTRACT
|
