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Application to Therapy

Ronald A. Castellino, MD; Harvey M. Goldstein, MD; Edward B. Stinson, MD; Randall B. Griepp, MD

JAMA. 1970;213(3):463-464.

Abstract
Pulmonary aspergillosis due to Aspergillus fumigatus followed cardiac transplantation in a 58-year-old man. Diagnosis was achieved by needle aspiration biopsy of a single cavitary lesion in the upper lobe of the right lung. A trial of intravenous amphotericin B therapy was unsuccessful in halting progress of the lesion. Needle aspiration of the lesion was repeated and a small polyethylene catheter was threaded into the cavity and left in place for long-term endocavitary irrigations with amphotericin B and sodium iodide. Endocavitary treatment was associated with clinical improvement and decrease in size of the lesion.

Author Affiliations
From the divisions of diagnostic radiology (Drs. Castellino and Goldstein) and cardiovascular surgery (Drs. Stinson and Griepp), Stanford University School of Medicine, Stanford, Calif.

Footnotes
Reprint requests to Division of Diagnostic Radiology, Stanford Medical Center, 300 Pasteur Dr, Stanford, Calif 94305 (Dr. Castellino).

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