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Hemolytic-Uremic Syndrome in Adults
Charles M. Shapiro, MD;
Alan Kanter, MD;
Harry Lopas, MD;
S. Frederick Rabiner, MD
JAMA. 1970;213(4):567-570.
Abstract
Two adults had the syndrome of acute microangiopathic hemolytic anemia and severe oliguric renal failure. Therapy with prednisone and careful attention to fluid balance, and peritoneal dialysis in one patient, were associated with complete reversal of the syndrome. Though the pathogenesis of thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS) may be similar, clinical distinction is of great importance in view of the favorable prognosis of HUS, whereas TTP is almost uniformly fatal. The presence of severe renal failure at the onset of any acute microangiopathic hemolytic anemia process should alert the clinician to the diagnosis of HUS.
Author Affiliations
From the divisions of clinical hematology (Drs. Shapiro, Lopas, and Rabiner) and nephrology (Dr. Kanter), Department of Medicine, Michael Reese Hospital and Medical Center, Chicago.
Footnotes
Reprint requests to 2839 S Ellis Ave, Chicago 60616 (Dr. Rabiner).
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