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Jaime A. Wikinski, MD; Jose E. Usubiaga, MD; Regina W. Wikinski, MD

JAMA. 1970;213(4):621-623.

Abstract
A 39-year-old patient inadvertently received 4,000 mg of procaine hydrochloride following administration of thiopental sodium, hexafluorenium bromide, and succinylcholine chloride. Mydriasis, pupils unreactive to light, arterial hypertension, sinus tachycardia, and deepening and widening of the S wave of the electrocardiogram immediately appeared, and lasted for several minutes. The level of procaine in the blood reached a peak of 96 µg/ml, and declined slowly after that. No generalized convulsions developed. The patient recovered spontaneously with no sequelae, a fact largely attributed to the protective effect of artificial ventilation with 100% oxygen.

Author Affiliations
From the departments of anesthesiology, Rawson Hospital, Buenos Aires (Dr. J. A. Wikinski), and the University of Miami (Fla) School of Medicine (Dr. Usubiaga), and the Institute of Analisis Clinicos, School of Pharmacy and Biochemistry, University of Buenos Aires (Dr. R. W. Wikinski).

Footnotes
Reprint requests to PO Box 875, Biscayne Annex, Miami, Fla 33152 (Dr. Usubiaga).

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