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Toru Furukawa, MD; Takao Miyata, MD; Keizo Kondo, MD; Kuniyoshi Kuno, MD; Shin Isomura, MD; Terko Takekoshi, MD

JAMA. 1970;213(6):987-990.

Abstract
A boys' school in Japan has suffered recurrent epidemics of rubella. Two epidemics occurred in 1969 which provided the opportunity to test the efficacy of the RA 27/3 rubella strain administered either subcutaneously or intranasally. At the outset of the first epidemic, some of the boys were given RA 27/3 rubella vaccine subcutaneously, whereas in the second RA 27/3 rubella vaccine given intranasally was tested. Good antibody responses were shown in vaccinees inoculated by both routes. As compared to unvaccinated controls, there was a sharp reduction in rubella cases among the vaccinees two weeks after inoculation. The protection produced by subcutaneous vaccination with RA 27/3 in the first epidemic was highly significant statistically. The second epidemic was too small for definite judgment, but intranasal administration of RA 27/3 also appeared to be effective.

Author Affiliations
From the Department of Pediatrics, Nagoya (Japan) University.

Footnotes
Reprint requests to the Wistar Institute, 36th & Spruce Streets, Philadelphia 19104 (Dr. Plotkin).

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