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The Marihuana-Induced "Social High"Neurological and Electroencephalographic Concomitants
Ernst A. Rodin, MD;
Edward F. Domino, MD;
James P. Porzak
JAMA. 1970;213(8):1300-1302.
Abstract
Ten healthy freshman medical students who had previous extensive experience with marihuana smoking were allowed to inhale the compound in the laboratory until they had reached their usual "high." The observed overall effects were mild or minimal. In the electroencephalogram, there occurred a slight but statistically significant shift toward slower  -frequencies. There were no significant changes in cerebral evoked responses. Results of the neurological examination remained normal. Vibratory sense appreciation improved slightly. Mental status examination showed a slight decrease in intellectual efficiency, some excess jocularity, and a slight loosening of associations. Bender-Gestalt drawings were executed slightly more poorly after drug inhalation than before. It is concluded that the subjective pleasure and relaxation which are experienced as a result of marihuana smoking are accompanied by a very slight decrease in highest cortical functions.
Author Affiliations
From the Neurological Research Division (Dr. Rodin), the Pharmacology Laboratory (Dr. Domino), and the Computer Laboratory (Mr. Porzak) of the Lafayette Clinic and the Department of Neurology, Wayne State University (Dr. Rodin), Detroit.
Footnotes
Reprint requests to 951 E Lafayette, Detroit 48207 (Dr. Rodin).
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