This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Hershel Jick, MD; Olli S. Miettinen, MD, PhD; Samuel Shapiro, MD; George P. Lewis, MD; Victor Siskind, PhD; Dennis Slone, MD

JAMA. 1970;213(9):1455-1460.

Abstract
The urgent need for information about clinical drug effects may be partially met by a large-scale comprehensive drugsurveillance program designed to permit the detection of unsuspected side effects and drug interactions, the quantitation of known effects, and the evaluation of the role of influencing factors. Such a program, the Boston Collaborative Drug Surveillance Program, now involving eight hospitals, is described, the principles and potential of this type of research are discussed, and data on some broad aspects of drug utilization and effects are presented. An appropriately designed drug-surveillance program can be introduced to hospital wards with a minimum of interference with the ward routine, can be applied in a standardized form in different centers, and is indeed capable of providing valuable information about clinical drug effects.

Author Affiliations
From the Clinical Pharmacology Unit, Lemuel Shattuck Hospital, the Department of Medicine, Tufts University School of Medicine, and the Department of Epidemiology, Harvard School of Public Health, Boston. Dr. Jick is a Burroughs-Wellcome scholar in clinical pharmacology.

Footnotes
Participating hospitals in the Boston Collaborative Drug Surveillance Program include Lemuel Shattuck Hospital, Peter Bent Brigham Hospital, Boston Veterans

Administration Hospital, and Boston City Hospital (Tufts Service), Boston, Roger Williams General Hospital, Providence, RI, St. Joseph's and Westminister Hospitals, London, Ontario, and the Hadassah Hebrew University Hospital, Jerusalem, Israel.

Reprint requests to Clinical Pharmacology Unit, 400 Totten Pond Rd, Waltham, Mass 02154 (Dr. Jick).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Learning how to control biases in studies to identify adverse effects of drugs: a brief personal history
Jick
JRSM 2009;102:160-164.
FULL TEXT  

Errors and adverse events in family medicine: Developing and validating a Canadian taxonomy of errors
Jacobs et al.
cfp 2007;53:270-276.
ABSTRACT | FULL TEXT  

Adverse drug event trigger tool: a practical methodology for measuring medication related harm
Rozich et al.
Qual Saf Health Care 2003;12:194-200.
ABSTRACT | FULL TEXT  

Medication Safety: Moving From Illusion to Reality
Classen
JAMA 2003;289:1154-1156.
FULL TEXT  

Methods of assessing unwanted effects of psychotropic drugs. General considerations and overview
Edwards
J Psychopharmacol 1992;6:191-197.
 

Assessment of epileptogenic potential: experimental, clinical and epidemiological approaches
Edwards and Wheal
J Psychopharmacol 1992;6:204-213.
ABSTRACT  

Drug-Induced Cutaneous Reactions: A Report From the Boston Collaborative Drug Surveillance Program on 15 438 Consecutive Inpatients, 1975 to 1982
Bigby et al.
JAMA 1986;256:3358-3363.
ABSTRACT  

Intensive Hospital Monitoring Study of Intravenous Cimetidine
Porter et al.
Arch Intern Med 1986;146:2237-2239.
ABSTRACT  

Nonsteroidal Anti-inflammatory Drugs and Renal Disease
Fox and Jick
JAMA 1984;251:1299-1300.
ABSTRACT  

Drug Monitoring of Surgical Patients
Danielson et al.
JAMA 1982;248:1482-1485.
ABSTRACT  

Effects of Aspirin and Acetaminophen in Gastrointestinal Hemorrhage: Results From the Boston Collaborative Drug Surveillance Program
Jick
Arch Intern Med 1981;141:316-321.
ABSTRACT  

The Role of latrogenic Disease in Admissions to Intensive Care
Trunet et al.
JAMA 1980;244:2617-2620.
ABSTRACT  

Predictors of Bleeding During Heparin Therapy
Walker and Jick
JAMA 1980;244:1209-1212.
ABSTRACT  

Postmarketing Follow-up
Jick et al.
JAMA 1979;242:2310-2314.
ABSTRACT  

Drug-Related Superinfection in Hospitalized Patients
Walker et al.
JAMA 1979;242:1273-1275.
ABSTRACT  

Lung Cancer in Young Women
Jick et al.
Arch Intern Med 1979;139:745-746.
ABSTRACT  

Drug Evaluation After Marketing
SLONE et al.
ANN INTERN MED 1979;90:257-261.
ABSTRACT  

Oral Contraceptives and Nonfatal Stroke in Healthy Young Women
JICK et al.
ANN INTERN MED 1978;89:58-60.
ABSTRACT  

Salt Substitutes as a Source of Potassium
Sopko and Freeman
JAMA 1977;238:608-610.
ABSTRACT  

Rates of Cutaneous Reactions to Drugs: A Report From the Boston Collaborative Drug Surveillance Program
Arndt and Jick
JAMA 1976;235:918-923.
ABSTRACT  

Toward Assessing the Chemical Age: Summary of Deliberations, 1974
The Special Commission on Internal Pollution
JAMA 1975;234:507-509.
ABSTRACT  

Amphetamines and Malignant Lymphoma: A Report From the Boston Collaborative Drug Surveillance Program
JAMA 1974;229:1462-1463.
ABSTRACT  

Relation of Body Weight and Insulin Dose to the Frequency of Hypoglycemia: A Report From the Boston Collaborative Drug Surveillance Program
JAMA 1974;228:192-194.
ABSTRACT  

Reduction of Digoxin Toxicity Associated with Measurement of Serum Levels: A Report from the Boston Collaborative Drug Surveillance Program
DUHME et al.
ANN INTERN MED 1974;80:516-519.
ABSTRACT  

Allopurinol and Cytotoxic Drugs: Interaction in Relation to Bone Marrow Depression
Boston Collaborative Drug Surveillance Program
JAMA 1974;227:1036-1040.
ABSTRACT  

Adverse Reactions to Spironolactone: A Report From the Boston Collaborative Drug Surveillance Program
Greenblatt and Koch-Weser
JAMA 1973;225:40-43.
ABSTRACT  

Drug-Induced Extrapyramidal Symptoms: A Cooperative Study
JAMA 1973;224:889-891.
ABSTRACT  

Drug-Induced Deafness: A Cooperative Study
JAMA 1973;224:515-516.
ABSTRACT  

Polypragmasy: A New Condition?
Stickler
CLIN PEDIATR 1972;11:441-441.
 

The Clinical Choice of Sedative-Hypnotics
GREENBLATT and SHADER
ANN INTERN MED 1972;77:91-100.
ABSTRACT  

Adverse Drug Interactions
Boston Collaborative Drug Surveillance Program Bos
JAMA 1972;220:1238-1239.
ABSTRACT  

Detection and Evaluation of Adverse Drug Reactions
Miller and Shapiro
JAMA 1972;220:1011-1011.
ABSTRACT  

Tetracycline and Drug-Attributed Rises in Blood Urea Nitrogen: A Report From the Boston Collaborative Drug Surveillance Program
JAMA 1972;220:377-379.
ABSTRACT  

Drug Interaction
Parke
The Journal of the Royal Society for the Promotion of Health 1972;92:65-68.
 

Experience in Monitoring Drug Reactions in Outpatients: The Kaiser-Permanente Drug Monitoring System
Friedman et al.
JAMA 1971;217:567-572.
ABSTRACT  

Fatal Drug Reactions Among Medical Inpatients
Shapiro et al.
JAMA 1971;216:467-472.
ABSTRACT