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Prevention of Posttransfusion Hepatitis by - Globulin

Preliminary Report

A Cooperative Study

JAMA. 1970;214(1):140-142.

Abstract
A prospective controlled study of 5,189 transfused cardiovascular surgery patients at 14 university hospital centers showed that hepatitis was not prevented or modified by 10 ml of -globulin given during the first, fourth, and seventh postoperative weeks, respectively. The incidence of hepatitis varied strikingly among the 14 participating study centers. Appropriate selection of blood donors was generally associated with a lower risk of hepatitis, a reduction which could be as much as 90% of average rates.

Author Affiliations
From (Coordinating Center) the Biologic Laboratories, State Laboratory Institute, and the Medical Service, Lemuel Shattuck Hospital, Massachusetts Department of Public Health, and departments of medicine and preventive medicine, Tufts University Medical School, Boston.

Footnotes
Report prepared by George F. Grady, MD, and Ann J. E. Bennett, Boston.

Investigators and Study Centers: George F. Grady, MD, John N. Forrest, Jr., MD, and T.C. Chalmers, MD, Boston; Fred Kern, Jr., MD, and John W. Singleton, MD, Denver; Allan G. Redeker, MD, Los Angeles; Howard F. Taswell, MD, and Rhiannon Shorter, MBBS, Rochester, Minn; John T. Galambos, MD, and James L. Achord, MD, Atlanta; Frank L. Iber, MD, Arthur Cocco, MD, and Thomas R. Hendrix, MD, Baltimore; Edsel K. Hudson, MD, and A. W. Holmes, MD, Chicago; Charles H. Brown, MD, and Eugene I. Winkelman, MD, Cleveland; Norton J. Greenberger, MD, and Richard Ruppert, MD, Columbus, Ohio; John M. Eiband, MD, Houston; Philip A. Christiansen, MD, Indianapolis; John W. Schaefer, MD, Lexington, Ky; James B. Carey, Jr., MD, PhD, and Charles Drage, MD, Minneapolis; John V. Carbone, MD, Lloyd L. Brandborg, MD, and Frederick London, MD, San Francisco.

Coordinating Center: Biologic Laboratories, Massachusetts Department of Public Health, Boston (George F. Grady, MD, Director; Ann J. E. Bennett, Assistant Director).

Steering Committee: George F. Grady, MD (Chairman); Thomas C. Chalmers, MD; Fred Kern, Jr., MD; Allan G. Redecker, MD; Howard F. Taswell, MD; and Hugo Muench, MD, DrPH.

Advisory Board: Geoffrey Edsall, MD (Chairman), Superintendent, State Laboratory Institute, Massachusetts Department of Public Health; Robert W. McCollum, MD, Professor and Chairman, Department of Preventive Medicine, Yale University School of Medicine, New Haven, Conn; James W. Mosley, MD, Associate Professor of Medicine, University of Southern California School of Medicine, Los Angeles; and Robert B. Pennell, PhD, Acting Scientific Director, Blood Research Institute,

Incorporated, Boston, Mass.

Reprint requests to 375 South St, Boston 02130 (Dr. Grady).

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