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LCDR Myron J. Tong, MC; CDR G. Thomas Strickland, MC; LCDR Bernhard A. Votteri, MC; CAPT Jean-Jacques Gunning, MC

JAMA. 1970;214(13):2330-2333.

Abstract
Seventy-five US marines who were treated with pyrimethamine, chloroquine phosphate, and sulfisoxazole for Plasmodium falciparum malaria, were supplemented with either folic acid, folinic acid, or a placebo. A reduced incidence of anemia and leukopenia, a more rapid reticulocytosis, and an increased platelet response were seen in both the folic and folinic acid supplemented groups. The antimalarial effect of pyrimethamine was not inhibited by the addition of folates to the treatment regimen. Folate supplements are recommended when pyrimethamine is used in the therapy of P falciparum malaria.

Author Affiliations
USNR; USN; USNR; USN

From the Naval Medical Research Unit No. 2 Detachment and the Department of Medicine, Naval Support Activity Hospital, DaNang, South Vietnam. Drs. Tong, Strickland, and Gunning are now with the Department of Clinical Investigation, US Naval Medical Research Unit No. 2, Taipei, Taiwan, Republic of China, and Dr. Votteri is now with the Department of Medicine, Wadsworth Veterans Administration Hospital, Los Angeles.

Footnotes
The opinions and assertions contained herein are those of the authors and are not to be construed as official, or as reflecting the views of the Navy Department or the Naval Service at large.

Reprint requests to Publications Editor, NAMRU-2, Box 14, APO San Francisco 96263.

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