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Avram Goldstein, MD; Byron W. Brown, Jr., PhD

JAMA. 1970;214(2):311-315.

Abstract
In the treatment of heroin addiction by methadone hydrochloride maintenance, it is customary to test urine specimens regularly, in order to monitor each patient's illicit use of drugs and to assess the general success of the program. Principles and graphs are presented here to aid the physician in choosing an economical testing frequency, and in interpreting the results quantitatively on a correct statistical basis. For most purposes, a random testing schedule at an average frequency of once in five days will suffice.

Author Affiliations
From the Department of Pharmacology and the Division of Biostatistics, Department of Community and Preventive Medicine, Stanford (Calif) University School of Medicine, and the Santa Clara County Methadone Program, San Jose, Calif.

Footnotes
Reprint requests to Department of Pharmacology, Stanford University School of Medicine, Stanford, Calif 94305 (Dr. Goldstein).

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