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John N. Crook, MD; Isidore Cohn, Jr., MD

JAMA. 1970;214(2):343-346.

Abstract
Anaerobic bacteria harbored in the liver of the dog have been shown to be the cause of death in this animal after hepatic artery ligation. The protective effect of antibiotics is well recognized. Forty-nine conventional and two germfree dogs were studied after hepatic artery ligation to evaluate this problem further. No conventional dogs survived without antibiotics. Antibiotics in large doses protected 81% of conventional dogs; 47% of dogs treated four days prior to surgery survived. The two germfree animals survived without antibiotics. This reaffirms the role of bacterial sepsis of the liver as the cause of death in the dog after hepatic artery ligation and emphasizes the small doses of antibiotics necessary for protection of conventional dogs and the survival of germfree dogs without antibiotics.

Author Affiliations
From the Department of Surgery, Louisiana State University School of Medicine, New Orleans.

Footnotes
Reprint requests to 1542 Tulane Ave, New Orleans 70112 (Dr. Crook).

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