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James L. Tullis, MD; John Hinman, MD; Mary T. Sproul, MA; Rita J. Nickerson, MA

JAMA. 1970;214(4):719-723.

Abstract
The incidence of posttransfusion hepatitis was significantly reduced by a transmembrane washing procedure on thawed, deglycerolized, previously frozen red blood cells (RBC). The method constitutes mechanical centrifugation, high glycerol concentration, slow freeze and thaw, and a 4-liter washing procedure for deglycerolization. Four cases of histologically proved hepatitis (one icteric, three anicteric) occurred in a control group of 104 recipients receiving 442 transfusions (median 3) of such RBC resuspended in autologous plasma, an incidence of 9 per 1,000. No hepatitis occurred in the treatment group receiving 623 transfusions (or a median of 4 units per patient) of such RBC resusThe incidence of posttransfusion hepatitis was significantly

Author Affiliations
From the Blood Research Institute, Inc., and the Department of Medicine, New England Deaconess Hospital; and the departments of preventive medicine and medicine, Harvard Medical School, Boston.

Footnotes
Reprint requests to 110 Francis St, Boston 02215 (Dr. Tullis).

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