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Polydipsia, Hydrochlorothiazide, and Water Intoxication
H. Richard Beresford, MD
JAMA. 1970;214(5):879-883.
Abstract
On receiving therapeutic doses of hydrochlorothiazide, two long-term compulsive water drinkers developed acute hyponatremic encephalopathy. Although pure water intoxication is a possible explanation for their symptoms, the circumstances suggest that hydrochlorothiazide had an important role. The most likely mechanism was that the urinary sodium loss evoked by the drug compounded the effects of oral water loading and produced an acute hyponatremic state. Among other possible mechanisms considered was that hydrochlorothiazide depressed free water clearance.
Author Affiliations
From the Department of Medicine (Division of Neurology), University of Colorado Medical Center and Denver General Hospital, Denver.
Footnotes
Reprint requests to Division of Neurology, Denver General Hospital, West Sixth Avenue and Cherokee Street, Denver 80204 (Dr. Beresford).
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