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Charles Lomanto, MD; William S. Howland, MD

JAMA. 1970;214(7):1257-1261.

Abstract
Halothane was believed to be the offending agent in five cases of suspected hepatitis. All the patients were women. Two had chronic active hepatitis proved by liver biopsy, but the diagnosis in the other three, including the woman who died, was not clearly established. Until a specific test for viral or halothane hepatitis is developed, the use of halogenated agents in any patient with known liver disease, sepsis, or a recent history of flu-like symptoms should be avoided. An arbitrary three-month period is observed between repeated halothane anesthesias.

Author Affiliations
From the Department of Anesthesiology, Memorial Sloan-Kettering Cancer Center, New York.

Footnotes
Reprint requests to 444 E 68th St, New York 10021 (Dr. Lomanto).

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