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The Use of Factor VIII and Factor IX Concentrates During Surgery
James N. George, MD;
Robert T. Breckenridge, MD
JAMA. 1970;214(9):1673-1676.
Abstract
Patients with classic hemophilia and Christmas disease can be effectively treated with human coagulation factor concentrates to allow required surgical procedures without undue risk. The results of such treatment of ten patients with hemophilia and four patients with Christmas disease who were either undergoing exploratory surgery of the abdomen, corrective orthopedic surgery, or dental extractions are reported. Factor VIII plasma levels were 30 to 80 units/100 ml at the time of operation and maintained at 20 to 60 units/100 ml for two to five days postoperatively. Factor IX plasma levels were 20 to 70 units/100 ml during surgery and maintained at 10 to 70 units/100 ml for up to five days postoperatively. These brief treatment periods are described to emphasize that prolonged therapy may not be essential in the surgical management of patients with hemorrhagic disorders.
Author Affiliations
From the Department of Medicine, University of Rochester School of Medicine and Dentistry; the Rochester General Hospital; and the Hemophilia Center of Rochester and Monroe County, Rochester, NY. Dr. George is now with the University of Texas Medical School, San Antonio.
Footnotes
Reprint requests to 1425 Portland Ave, Rochester, NY 14621 (Dr. Breckenridge).
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