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Robert J. Cowan, MD; C. Douglas Maynard, MD; Richard L. Witcofski, PhD; Richard Janeway, MD; James F. Toole, MD

JAMA. 1971;215(6):978-979.

Abstract
Of 20 patients with myasthenia gravis studied with selenomethionine Se 75 mediastinal scans, two (10%) had positive scans. Both of these patients underwent surgery with removal of a thymoma. Since this radiopharmaceutical is accumulated in numerous tissues, false-positive studies may present some difficulty. The adult thymus, in the absence of a thymoma, does not appear to concentrate selenomethionine Se 75 sufficiently for external scanning. Negative studies may therefore be of value in ruling out the presence of a thymoma.

Author Affiliations
From the departments of radiology (Drs. Cowan, Maynard, and Witcofski) and neurology (Drs. Janeway and Toole), Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC. Dr. Cowan is a James Picker Scholar in Radiological Research.

Footnotes
Reprint requests to 300 S. Hawthorne Rd, Winston-Salem, NC 27103 (Dr. Cowan).

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