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Studies On Active Immunization

Saul Krugman, MD; Joan P. Giles, MD; Jack Hammond, MD

JAMA. 1971;217(1):41-45.

Abstract
Viral hepatitis, type B (MS-2) was prevented by active and passive immunization. Active immunization was induced by inoculation of a boiled, inactivated preparation of a 1:10 dilution of MS-2 serum in distilled water; two inoculations at four-month intervals were more effective than one. However, one inoculation gave enough protection to prevent some cases and modify others.

Author Affiliations
From the Department of Pediatrics, New York University School of Medicine, New York, and the Willowbrook State School, Staten Island, NY.

Footnotes
Read in part as an Honor's Lecture, New York University School of Medicine, March 23, 1971; before a meeting of the American Epidemiological Society, New Haven, Conn, April 3, 1971; and before a meeting of the American Pediatric Society, Atlantic City, NJ, April 29, 1971.

Reprint requests to 550 First Ave, New York 10016 (Dr. Krugman).

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