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Herpesvirus Antibody and Carcinoma in Situ of the Cervix
Louis W. Catalano, Jr., MD;
Lorna D. Johnson, MD
JAMA. 1971;217(4):447-450.
Abstract
Herpesvirus hominis type 2 antibodies were present in 35.7% of patients who subsequently developed carcinoma in situ of the cervix, whereas type 2 antibodies were present in 7.1% of matched controls who did not develop carcinoma in situ during the same period of observation. Type 2 antibodies were present in a significantly greater percent of patients with carcinoma in situ (42.0) than matched controls (17.7). After cervical conization and presumptive cure of carcinoma in situ, however, type 2 antibodies were present in a smaller percent of patients (9.1) than matched controls (31.8). The data suggests that previous herpesvirus type 2 infection is associated not only with the precursory stages of invasive cancer, but also precedes the earliest intraepithelial changes which develop into carcinoma in situ.
Author Affiliations
From the Laboratory of Biomedical Sciences, National Institute of Child Health and Human Development, and the Section on Infectious Diseases, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Md (Dr. Catalano), and the departments of pathology, and obstetrics and gynecology, Harvard Medical School and the Boston Hospital for Women (Lying-In Division), Boston (Dr. Johnson). Dr. Catalano is now with the College of Physicians and Surgeons, New York.
Footnotes
Reprint requests to 710 W 168th St, New York 10032 (Dr. Catalano).
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