This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Efficacy 14 Months After Immunization

Hjordis M. Foy, MD, PhD; Marion K. Cooney, PhD; Ruth McMahan, MN; Eva Bor, MD; J. Thomas Grayston, MD

JAMA. 1971;217(8):1067-1071.

Abstract
A controlled field study to evaluate the efficacy of a single dose of monovalent influenza A₂/Hong Kong vaccine was conducted among Seattle area school children in late fall of 1968. Concurrent epidemics of influenza A and influenza B occurred from December 1968 through February of 1969. Approximately 14 months after administration of vaccine, an epidemic of influenza due to A₂/Hong Kong strain occurred in this same population, with the epidemic peak in January 1970. This afforded us the opportunity to examine the long-term effect of the vaccine. Protection lasting 14 months after immunization was evident by (1) significantly less absenteeism from school, (2) 58% reduction of reported influenza-like illness, (3) 72% to 76% reduction in infection rates as estimated by serologic testing, and (4) 80% to 83% reduction in the rate of serologically confirmed influenza illness.

Author Affiliations
From the departments of epidemiology and international health, and pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle.

Footnotes
Reprint requests to School of Public Health and Community Medicine, Department of Epidemiology and International Health, University of Washington, Seattle 98105 (Dr. Foy).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Correlation of Cellular Immune Responses with Protection against Culture-Confirmed Influenza Virus in Young Children
Forrest et al.
CVI 2008;15:1042-1053.
ABSTRACT | FULL TEXT  

How Contagious Are Common Respiratory Tract Infections?
Musher
NEJM 2003;348:1256-1266.
FULL TEXT  

The Current Status of Influenza Vaccines
Eickhoff
JAMA 1974;230:1046-1047.
ABSTRACT  

A/Hong Kong Influenza Immunity Three Years After Immunization
Foy et al.
JAMA 1973;226:758-761.
ABSTRACT  

Protection With Split and Whole Virus Vaccines Against Influenza
Ruben et al.
Arch Intern Med 1973;132:568-571.
ABSTRACT