This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Jochewed Werch, MD; Richard E. Gray, MD; Theodore Hersh, MD; Joseph L. Melnick, PhD

JAMA. 1971;218(1):93-94.

Abstract
Viral hepatitis has not been reported following transfusion with frozen blood. Seven such samples from donors positive for Australia (Au/SH) antigen were studied. After thawing, Au/SH antigen was found in five of seven discarded wash solutions and in only one of the seven supernatant reconstituting saline solutions which form part of the transfused product. The positive sample came from a patient who had the highest titer of Au/SH antigen in his serum. The freeze-thaw processing appears to dilute out serum hepatitis and the associated Au/SH antigen, so that overt hepatitis does not follow administration of frozen blood.

Author Affiliations
From the departments of pathology (Drs. Werch and Gray), medicine (Dr. Hersh), and virology and epidemiology (Dr. Melnick), Baylor College of Medicine; and the Department of Pathology (Drs. Werch and Gray), Ben Taub General Hospital, Houston.

Footnotes
Reprint requests to 1200 Moursund Ave, Houston 77025 (Dr. Werch).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Decreased Incidence of Transfusion Hepatitis After Exclusive Transfusion with Reconstituted Frozen Erythrocytes: Studies in a Dialysis Unit
CARR et al.
ANN INTERN MED 1973;78:693-695.
ABSTRACT