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Prevention With Specific Hepatitis B Immune Serum Globulin

Saul Krugman, MD; Joan P. Giles, MD; Jack Hammond, MD

JAMA. 1971;218(11):1665-1670.

Abstract
A specific hepatitis B immune serum globulin preparation was effective for the prevention or modification of viral hepatitis, type B. All 11 children who had a parenteral exposure to MS-2 serum had evidence of hepatitis B infection after an average incubation period of 68 days. In contrast, of ten children who received hepatitis B immune serum globulin four hours after a parenteral exposure to MS-2 serum, (1) six were completely protected, five with evidence of passive-active immunity, (2) one had a transient infection for six days followed by the appearance of antibody, and (3) three had classical viral hepatitis, type B, after an average incubation period of 110 days. Under the conditions of this controlled study hepatitis B immune serum globulin was 70% effective.

Author Affiliations
From the Department of Pediatrics, New York University School of Medicine, New York, and the Willowbrook State School, Staten Island, NY.

Footnotes
Read in part before the 40th annual meeting of the American Academy of Pediatrics, Chicago, Oct 19, 1971.

Reprint requests to 550 First Ave, New York 10016 (Dr. Krugman).

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