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Frequency and Pattern of Response as Detected by Radioimmunoprecipitation

Jerrold J. Lander, MD; Paul V. Holland, MD; Harvey J. Alter, MD; Robert M. Chanock, MD; Robert H. Purcell, MD

JAMA. 1972;220(8):1079-1082.

Abstract
Serum samples from a human population group in the Washington, DC, area and from a chimpanzee colony in Arizona were tested for antibody to hepatitis-associated antigen (anti-HAA) by the redioimmunoprecipitation technique. Anti-HAA was detected in 64 of 324 (20%) persons tested; an age-specific increase in frequency and geometric mean titer of anti-HAA was observed. There was no difference in frequency between males and females. Forty-six of 81 chimpanzees tested were found to have anti-HAA; the frequency of this antibody also increased with age. IgM and IgG anti-HAA were measured in ten patients who developed anti-HAA after what was thought to be primary exposure to HAA. IgM and IgG anti-HAA were detected in all ten patients. No specific patterns of IgM or IgG anti-HAA response were detected.

Author Affiliations
From the National Institute of Allergy and Infectious Diseases, Laboratory of Infectious Diseases (Drs. Lander, Chanock, and Purcell), and the Blood Bank Department, Clinical Center (Drs. Holland and Alter), National Institutes of Health, Bethesda, Md.

Footnotes
Reprint requests to National Institutes of Health, NIAID, LID, Building 7, Bethesda, Md 20014 (Dr. Purcell).

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