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Case Report and Review of the Literature

Edmund L. Dubois, MD; Edward Tallman, MD; Richard A. Wonka, MD

JAMA. 1972;221(6):595-596.

Abstract
A 38-year-old man developed polyarthritis, light-sensitive butterfly area eruption, pleurisy with effusion, leukopenia, and fever after taking 400 mg of chlorpromazine daily for 17 months. Lupus erythematosus (LE) cells and antinuclear antibodies (ANA) were present. Following cessation of the medication, improvement occurred within two weeks; symptoms recurred on challenging with chlorpromazine within 36 hours. The LE cells and ANA disappeared two months after the drug was withdrawn.

Author Affiliations
From the Rheumatic Disease and Immunology Section, Department of Medicine, University of Southern California School of Medicine (Dr. Dubois), and the Department of Psychiatry, UCLA Medical Center, Los Angeles (Drs. Tallman and Wonka).

Footnotes
Reprint requests to University of Southern California School of Medicine, 2025 Zonal Ave, Los Angeles 90033 (Dr. Dubois).

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