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Experience in the Coronary Drug Project

The Coronary Drug Project Research Group

JAMA. 1973;223(10):1116-1124.

Abstract
Two hundred thirty-five men among 2,035 survivors of myocardial infarction (11.5%) had one or more ventricular premature beats (VPB) in their resting base-line electrocardiogram. During a three-year follow-up period, deaths were about twice as frequent in those with any VPB (21.7%) as in those with none (11.4%) among the placebo-treated patients in the nationwide Coronary Drug Project.

Excess long-term risk of death, including sudden death, was associated with the frequency of VPB, with VPB in pairs or runs, and possibly with early-cycle VPB. The excess risk with these VPB characteristics was independent of the risk associated with other electrocardiographic and clinical characteristics.

Footnotes
Prepared by Suketami Tominaga, MD, and Henry Blackburn, MD.

For a complete list of the key bodies of the Coronary Drug Project and senior staff members see p 1123.

Reprint requests to ECG Center, Coronary Drug Project, Laboratory of Physiological Hygiene, Stadium Gate 27, University of Minnesota, Minneapolis 55455 (Henry Blackburn, MD).

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