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Obaid U. Rehman, MD; Thomas A. Keith, MD; Edward A. Gall, MD

JAMA. 1973;224(10):1390-1392.

Abstract
A 51-year-old woman developed jaundice after two separate administrations of methyldopa. The second administration resulted in submassive hepatic necrosis. This unfortunate fatality resulted from a reaction that, as heretofore reported, has been less severe with this particular drug.

Author Affiliations
From the departments of pathology (Dr. Gall) and medicine (Drs. Rehman and Keith), Cincinnati General Hospital, University of Cincinnati Medical Center, Cincinnati.

Footnotes
Reprint requests to Cincinnati General Hospital, Ohio 45219 (Dr. Keith).

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