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Occurrence in a Patient With Leukemia

Lawrence S. Richman, MD; Welland F. Short, MD; William M. Cooper, MD

JAMA. 1973;226(1):62-63.

Abstract
A patient with acute leukemia and depressed bone marrow following chemotherapy developed a Clostridium perfringens septicemia immediately following a barium enema examination.

Autopsy showed ulcerated colonic mucosa with phagocytized bacteria within the colonic wall. There was no leukemic involvement of the colon nor was there any intestinal perforation.

Comparison of the antemortem and postmortem bacteriological findings as well as the temporal relationship leads us to incriminate the barium enema as the prime causative factor in this patient's fatal septicemia.

Author Affiliations
From the departments of radiology (Drs. Richman and Short) and internal medicine (Dr. Cooper), University of Pittsburgh School of Medicine, Pittsburgh.

Footnotes
Reprint requests to Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh 15213 (Dr. Richman).

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