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A Complication of Mumps

David Y. Graham, MD; Clarence H. Brown III, MD; Jaime Benrey, MD; Janet S. Butel, PhD

JAMA. 1974;227(10):1162-1164.

Abstract
The mechanism of thrombocytopenia associated with mumps was investigated in a case proved by virus isolation. Although an immune mechanism for the thrombocytopenia has been postulated, platelet agglutinins, clot retraction inhibitors, complement-fixing platelet antibodies, or stimulation of platelet factor 3 availability could not be demonstrated in either the presence or absence of mumps-specific antigens. These results suggest that thrombocytopenia is not a consequence of antibodies directed against normal platelets nor against mumps antigen adsorbed to platelets. Rather, it appears that in this disorder, thrombocytopenia may result from a direct action of the virus or a viral antigen-antibody complex on platelets.

Author Affiliations
From the departments of medicine (Drs. Graham, Benrey, and Brown), virology and epidemiology (Dr. Butel), Baylor College of Medicine, Houston.

Footnotes
Reprint requests to 1200 Moursand, Houston, TX 77025 (Dr. Graham).

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