This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Comparison of Spironolactone and a Hydrochlorothiazide-Triamterene Combination

Janice G. Douglas, MD; John W. Hollifield, MD; Grant W. Liddle, MD

JAMA. 1974;227(5):518-521.

Abstract
Seventeen patients with low-renin essential hypertension were studied in a double-blind comparison of the antihypertensive effect of spironolactone with that of a hydrochlorothiazide-triamterene combination. All 17 patients responded to spironolactone. The decrease in average mean blood pressure was 20.7 mm Hg accompanied by an average diuresis of —3.1 kg. Fourteen of the 17 patients had favorable responses to hydrochlorothiazide-triamterene. The average decrease in mean blood pressure was 17.0 mm Hg, and the average diuresis was —1.5 kg. The difference in mean blood pressure response was not statistically significant.

The fact that both forms of therapy were effective, even though their mechanisms of action differ, suggests that extracellular fluid volume reduction may be the key factor in the amelioration of hypertension in patients with "low-renin essential hypertension."

Author Affiliations
From the Department of Medicine, Vanderbilt University Hospital, Nashville, Tenn.

Footnotes
Reprint requests to Vanderbilt University Hospital, Nashville, TN 37232 (Dr. Liddle).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Blood Pressure Responses to Small Doses of Amiloride and Spironolactone in Normotensive Subjects
Pratt et al.
Hypertension 2001;38:1124-1129.
ABSTRACT | FULL TEXT  

Dietary Sodium and Essential Hypertension: Some Myths, Hopes, and Truths
LARAGH and PECKER
ANN INTERN MED 1983;98:735-743.
ABSTRACT  

Psychosexual Adjustment and Counseling After Myocardial Infarction
McLANE et al.
ANN INTERN MED 1980;92:514-519.
ABSTRACT  

Short-term Therapy of Severe Hypertension: Hemodynamic Correlates of the Antihypertensive Response in Man
Sullivan et al.
Arch Intern Med 1979;139:1233-1239.
ABSTRACT  

A Composite Analysis of Renin Classification Methods
Holle et al.
Arch Intern Med 1978;138:1514-1519.
ABSTRACT  

Diuretic Therapy and Response of Essential Hypertension to Saralasin
ANDERSON et al.
ANN INTERN MED 1977;87:183-187.
ABSTRACT  

Effects of Guanethidine and Methyldopa on a Standardized Test for Renin Responsiveness
LOWDER and LIDDLE
ANN INTERN MED 1975;82:757-760.
ABSTRACT