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A Report of Six Cases

Kent Brownlow, PhD; Franklin R. Elevitch, MD

JAMA. 1974;230(8):1141-1144.

Abstract
Serum creatine phosphokinase (CPK) isoenzyme levels were studied in six cases: two with polymyositis, two with dermatomyositis, and two with viral myositis without neurological involvement. In all patients, agarose gel fractionation and fluorometric quantitation of serum CPK isoenzymes showed the presence of CPK₂, although there was no evidence of myocardial infarction. Thus, CPK₂ is not exclusively found in myocardial infarction. The prolonged elevation of CPK₂ levels during periods of acute exacerbation of myositis in the reported cases is in contrast to the usual transient increases in myocardial infarction. Levels of serum lactate dehydrogenase (LDH), aspartate aminotransferase, and aldolase were invariably increased in these patients. The expected LDH₅ increase with myositis was not found.

(JAMA 230:1141-1144, 1974)

Author Affiliations
From the Department of Pathology and Laboratory Medicine, Mount Zion Hospital and Medical Center, San Francisco. Dr. Brownlow is now at Corning Glass Works, Palo Alto, Calif.

Footnotes
Reprint requests to 1600 Divisadero St, San Francisco, CA 94115 (Dr. Elevitch).

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