This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Edwin Shuttleworth, MD; Gary Wise, MD; George Paulson, MD

JAMA. 1974;230(8):1170-1171.

Abstract
Three patients who had excessive diphenylhydantoin blood levels (29µg, 30µg, and 43µg per milliliter) developed choreoathetosis. The involuntary movements rapidly disappeared with a reduction of the diphenylhydantoin dose. One of the three patients did not have any of the common neurologic signs of diphenylhydantoin toxicity. The mechanism for the production of this phenomenon with excessive diphenylhydantoin is unknown, but it appears that the reaction is most likely to occur in epileptic patients with decreased intellect or persistent neurologic signs.

(JAMA 230:1170-1171, 1974)

Author Affiliations
From the Division of Neurology, Ohio State University Hospital (Drs. Shuttleworth, Wise, and Paulson), and the Riverside Methodist Hospital (Dr. Paulson), Columbus, Ohio.

Footnotes
Reprint requests to Means Hall, Room 43, 466 W 10th Ave, Columbus, OH 43210.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Phenytoin-Diazepam Interaction
Murphy and Wilbur
The Annals of Pharmacotherapy 2003;37:659-663.
ABSTRACT | FULL TEXT  

Phenytoin-induced Movement Disorder Associated with Intravenous Administration for Status Epilepticus
Howrie and Crumrine
CLIN PEDIATR 1985;24:467-469.