Imipramine-induced heart block. A longitudinal case study
S. J. Kantor, J. T. Bigger Jr, A. H. Glassman, D. L. Macken and J. M. Perel
A 2:1 atrioventricular block developed during treatment with the tricyclic
antidepressant imipramine in a 74-year-old man with a three-year history of
right bundle-branch block. Serial cardiographic studies and determinations
of blood imipramine concentrations showed that the heart block was directly
related to the plasma concentration of the drug and occurred below the
atrioventricular node in the His-Purkinje system.
