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W. Richard Smith, MD; Archie F. Wilson, MD, PhD

JAMA. 1975;231(13):1367-1368.

Abstract
In two cases of Guillain-Barré syndrome (acute polyneuritis) as a complication of narcotic abuse, the onset of paralysis began approximately 4 and 12 hours after self-administration of opiates intravenously. Bulbar and respiratory paralysis developed in one patient and required prolonged ventilation therapy; the other patient had peripheral muscular and unilateral facial weakness, with minimal respiratory involvement. Increased spinal fluid protein without notable pleocytosis was present in both.

(JAMA 231:1367-1368, 1975)

Author Affiliations
From the Department of Medicine, University of California, Irvine.

Footnotes
Reprint requests to Department of Medicine, University of California, Irvine, CA 92664 (Dr. Smith).

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