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Comparison of Methyldopa and Hydrochlorothiazide in Combination and Singly

F. Gilbert McMahon, MD

JAMA. 1975;231(2):155-158.

Abstract
In a double-blind clinical evaluation, the efficacy of a combination of methyldopa with hydrochlorothiazide was compared with that of its components, methyldopa and hydrochlorothiazide. The combination was found to be more efficacious than either of its components. It reduced the arithmetic mean of the pressures of all patients from 170/116 to 133/95 mm Hg in four weeks. Despite the greater effect of the combination, side effects were mild.

(JAMA 231:155-158, 1975)

Author Affiliations
From the Department of Medicine, Tulane University School of Medicine, New Orleans.

Footnotes
Reprint requests to Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112 (Dr. McMahon).

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