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Overnight Excretion of Catecholamine Metabolites

Jay M. Sullivan, MD; Harold S. Solomon, MD

JAMA. 1975;231(6):618-619.

Abstract
The diurnal variation of urinary vanillylmandelic acid (VMA) and metanephrine-normetanephrine levels was studied in six patients with pheochromocytoma and 32 patients with essential hypertension. Despite variable degrees of day-night differences, urinary excretion of VMA and metanephrines, per unit of time or per gram of urinary creatinine, was invariably higher in patients with pheochromocytoma than in controls whether the collection was 7 AM through 7 PM or 7 PM through 7 AM. Thus, shorter study periods are sufficient to exclude the presence of a chromaffinoma in most patients with hypertension.

(JAMA 231:618-619, 1975)

Author Affiliations
From the Department of Medicine, Hypertension Unit, Peter Bent Brigham Hospital, and Harvard Medical School, Boston, Mass. Dr. Sullivan is now at the University of Tennessee Center for the Health Sciences, Memphis.

Footnotes
Reprint requests to Department of Medicine, University of Tennessee Center for the Health Sciences, 951 Court Ave, Memphis, TN 38163 (Dr. Sullivan).

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ABSTRACT