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Trimethoprim-Sulfamethoxazole (Bactrim, Septra)

Donald O. Schiffman, PhD

JAMA. 1975;231(6):635-637.

Abstract
Trimethoprim and sulfamethoxazole, combined in a synthetic anti-infective preparation, act synergistically to inhibit the growth of certain microorganisms. This combination is effective orally in acute and chronic urinary tract infections. It also has been used successfully to treat other infectious conditions, including bacterial upper respiratory tract infections, ear infections, skin and soft-tissue infections, septicemias, acute and subacute bacterial endocarditis, enteric fever, brucellosis, prostatitis, and gonorrhea. It is well tolerated by most patients.

(JAMA 231:635-537, 1975)

Author Affiliations
Dr. Schiffman is Senior Scientist, AMA Department of Drugs. This communication was prepared with the assistance of consultants.

Footnotes
Scientific data on the trimethoprim-sulfamethoxazole combination were supplied by Roche Laboratories, Nutley, NJ, and Burroughs Wellcome Co, Research Triangle Park, NC.

Reprint requests to Department of Drugs, American Medical Association, 535 N Dearborn St, Chicago, IL 60610.

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