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A Parallel Study With a 10% Solution and a Non-Enteric-Coated Waxy-Matrix Tablet

J. Alfred Rider, MD, PhD; Richard J. Manner, MD; Joyce I. Swader

JAMA. 1975;231(8):836-837.

Abstract
Concentrated potassium chloride produces ulceration of the gastrointestinal mucosa. Dilute solutions are frequently not acceptable to the patient. A tablet containing potassium chloride crystals suspended in a waxy matrix has been developed to avoid these drawbacks. We measured fecal blood loss by a radioactive chromium technique on 20 subjects during five days while they were given potassium chloride, 40 mEq/day; ten subjects took a 10% solution; the others the waxy-matrix tablet. Fecal blood loss did not differ significantly between these groups. Mean fecal blood losses in both groups were slightly increased during the potassium chloride administration but never exceeded acceptable normal limits.

(JAMA 231:836-837, 1975)

Author Affiliations
From the Gastrointestinal Research Laboratory, Ralph K. Davies Medical Center, San Francisco (Dr. Rider and Ms. Swader), and the Warren-Teed Research Center, Columbus, Ohio (Dr. Manner).

Footnotes
Reprint requests to Ralph K. Davies Medical Center, Castro and Duboce streets, San Francisco, CA 94114 (Dr. Rider).

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