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David P. Shreiner, MD

JAMA. 1975;231(8):838-840.

Abstract
A young man with acute lymphoblastic leukemia was treated with vincristine sulfate, prednisone, and intrathecally injected methotrexate sodium for central nervous system involvement. A good remission was induced, but three months later he had hepatosplenomegaly, an enlarging mediastinal mass, and progressive anemia. Histiocytic medullary reticulosis was confirmed by a bone marrow biopsy specimen. The patient died of respiratory failure because of infiltration of the lungs by malignant histiocytes.

(JAMA 231:838-840, 1975)

Author Affiliations
From the Department of Medicine, Oakland Veterans Administration Hospital, and the University of Pittsburgh Medical School, Pittsburgh.

Footnotes
Reprint requests to Department of Medicine, Veterans Administration Hospital, University Drive, Pittsburgh, PA 15240 (Dr. Shreiner).

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