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Ray W. Newton, MB, MRCP

JAMA. 1975;231(9):941-943.

Abstract
Following intravenous administration of physostigmine salicylate for tricyclic antidepressant poisoning in 21 patients, convulsions occurred in two patients, and severe cholinergic manifestations occurred in two others. Because of these untoward effects and the very short duration of its beneficial action, it is very doubtful that physostigmine has any place in the routine management of tricyclic antidepressant poisoning.

(JAMA 231:941-943, 1975)

Author Affiliations
From the Regional Poisoning Treatment Centre, Royal Infirmary, Edinburgh. Dr. Newton is now with Ninewells Hospital, Dundee, Scotland.

Footnotes
Reprint requests to Senior Medical Registrar, Ninewells Hospital, Dundee, Scotland (Dr. Newton).

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