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  Vol. 232 No. 11, June 16, 1975 TABLE OF CONTENTS
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Hazards of Overconcentrated Milk Formula

Hyperosmolality, Disseminated Intravascular Coagulation, and Gangrene

Cyril A. L. Abrams, MD; Louise L. Phillips, PhD; Carol Berkowitz, MD; Piers R. Blackett, MD; Cedric J. Priebe, Jr., MD

JAMA. 1975;232(11):1136-1140.


Abstract

Severe hypertonic dehydration with hyperglycemia developed in a 7-week-old infant girl after she was fed an overconcentrated milk formula for five days. Renal failure, disseminated intravascular coagulation, gangrene of the legs, and coma were added complications.

Intravenous rehydration, peritoneal dialysis, and heparin administration corrected the metabolic and coagulation derangements, and renal function returned to normal. Bilateral below-the-knee amputations were performed and the child subsequently learned to walk with artificial limbs.

The dangers of overconcentrated formulas in infant feeding should be widely publicized through warnings printed on all commercial milk preparations.

(JAMA 232:1136-1140, 1975)



Author Affiliations

From the departments of pediatrics (Drs. Abrams, Berkowitz, and Blackett), obstetrics and gynecology (Dr. Phillips), and surgery (Dr. Priebe), The Roosevelt Hospital, and the College of Physicians and Surgeons, Columbia University, New York.


Footnotes

Reprint requests to The Roosevelt Hospital, 428 W 59th St, New York, NY 10019 (Dr. Abrams).



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