This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (22)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Hyperosmolality, Disseminated Intravascular Coagulation, and Gangrene

Cyril A. L. Abrams, MD; Louise L. Phillips, PhD; Carol Berkowitz, MD; Piers R. Blackett, MD; Cedric J. Priebe, Jr., MD

JAMA. 1975;232(11):1136-1140.

Abstract
Severe hypertonic dehydration with hyperglycemia developed in a 7-week-old infant girl after she was fed an overconcentrated milk formula for five days. Renal failure, disseminated intravascular coagulation, gangrene of the legs, and coma were added complications.

Intravenous rehydration, peritoneal dialysis, and heparin administration corrected the metabolic and coagulation derangements, and renal function returned to normal. Bilateral below-the-knee amputations were performed and the child subsequently learned to walk with artificial limbs.

The dangers of overconcentrated formulas in infant feeding should be widely publicized through warnings printed on all commercial milk preparations.

(JAMA 232:1136-1140, 1975)

Author Affiliations
From the departments of pediatrics (Drs. Abrams, Berkowitz, and Blackett), obstetrics and gynecology (Dr. Phillips), and surgery (Dr. Priebe), The Roosevelt Hospital, and the College of Physicians and Surgeons, Columbia University, New York.

Footnotes
Reprint requests to The Roosevelt Hospital, 428 W 59th St, New York, NY 10019 (Dr. Abrams).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Bacterial Contamination and Over-Dilution of Commercial Infant Formula Prepared by HIV-Infected Mothers in a Prevention of Mother-to-Child Transmission (PMTCT) Programme, South Africa
Andresen et al.
J Trop Pediatr 2007;0:fmm059v1-fmm059.
ABSTRACT | FULL TEXT  

Osmolality of Commonly Used Medications and Formulas in the Neonatal Intensive Care Unit
Jew et al.
Nutr Clin Pract 1997;12:158-163.
ABSTRACT  

Improper Mixing of Formula Due to Reuse of Hospital Bottles
Green and Moyer
Arch Pediatr Adolesc Med 1995;149:97-99.
ABSTRACT  

Hypernatremic Dehydration of Infancy: An Epidemiologic Review
Paneth
Arch Pediatr Adolesc Med 1980;134:785-792.
ABSTRACT  

Modern Day Menstrual Folklore: Some Clinical Implications
Snow and Johnson
JAMA 1977;237:2736-2739.
ABSTRACT