Renal transplantation in congenital and metabolic diseases. A report from the ASC/NIH renal transplant registry
The results of kidney transplantation in a variety of renal diseases have
been analyzed. The diseases causing end-stage kidney failure in recipients
were Alport syndrome, amyloidosis, cystinosis, diabetes mellitus, Fabry
disease, familial nephritis, gout, medullary cystic disease, oxalosis, and
systemic lupus erythematosus. The data indicate that renal transplantation
is justifiable and parallels functional results for the more common causes
of end-stage renal disease in all but Fabry disease and oxalosis. Although
Fabry disease did not recur in any grafted kidney, only three patients have
a functioning graft one year after transplantation. From a group of ten
patients with oxalosis who received a total of 14 kidneys, only one
survives. In no other metabolic disease, except one instance of primary
amyloidosis, did the metabolic disease notably affect the transplant as it
did in oxalosis.
