Hyperlipoproteinemia in occlusive cerebrovascular disease
N. T. Mathew, D. Davis, J. S. Meyer and K. Chandar
The distribution of occlusive atherosclerotic lesions in the aortocranial
circulation as determined by arteriography was correlated with results of
plasma lipid and lipoprotein determinations of patients with symptoms and
signs of cerebrovascular disease. The incidence of hyperlipoproteinemia in
the total study population was 31.8%. The frequency of hyperlipoproteinemia
was signigicantly higher in patients with atherosclerotic lesions limited
to extracranial (51%) and intracranial major vessels (44.2%) when compared
to the total number of patients and patients with only intracranial
small-vessel disease (P less than .05). Type IV hyperlipoproteinemia was
the most common abnormality (extracranial group, 42% type IV, 9% type II;
intracranial major-vessel group, 35.8% type IV, 8.4% type II). Patients
with intracranial small-vessel disease had the lowest frequency of
hyperlipoproteinemia (14.2%). The frequency of hypertension with or without
hyperlipoproteinemia was higher in patients with intracranial small-vessel
disease (P less than .01).
