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Treatment With Topically Applied Fluorouracil

LTC D. Klaus Goette, MC; Mervyn Elgart, MD; MAJ Richard L. DeVillez, MC

JAMA. 1975;232(9):934-937.

Abstract
Three patients with biopsy-confirmed erythroplasia of Queyrat were treated with topically applied fluorouracil. The lesions cleared completely, and recurrence-free follow-up periods ranged from 20 to 60 months. There were normal histological findings in posttreatment biopsy specimens in two of the patients.

A literature review yielded five additional cases successfully treated with fluorouracil applied topically. Patients with histologically confirmed erythroplasia of Queyrat should be afforded treatment with topically applied fluorouracil, as results appear to be superior to those of surgical or radiological treatment, with less morbidity.

(JAMA 232:934-937, 1975)

Author Affiliations
USA; USA

From the departments of dermatology, Walter Reed General Hospital (LTC Goette), the George Washington University School of Medicine (Dr. Elgart), Washington, DC, and the Brooke Army Medical Center, Fort Sam Houston, Tex (MAJ DeVillez). Dr. Goette is now at the Letterman Army Medical Center, San Francisco.

Footnotes
The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

Reprint requests to Dermatology Service, Box 172, Letterman Army Medical Center, Presidio of San Francisco, CA 94129 (LTC Goette).

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