Acute granulomatous hepatitis. Occurrence in cytomegalovirus mononucleosis
H. L. Bonkowsky, R. V. Lee and G. Klatskin
Two previously healthy adults with acute granulomatous hepatitis
attributable to cytomegalovirus (CMV) monucleosis had prolonged fever,
heterophil-negative lymphocytosis with numerous atypical forms, minor
alterations in hepatic function, and evidence on biopsy, of a nonspecific
acute hepatitis with granulomata. Infection with CMV was corroborated by a
rising titer of complement-fixing antibody in case 1 and by a high titer of
antibody that later fell in case 2. It is important to exclude CMV
ivfection as an etiologic factor in cases of acute granulomatous hepatitis
and fever of unknown origin.
