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A New Antihypertensive Agent

Mary Ellen Kosman, PhD

JAMA. 1975;233(2):174-176.

Abstract
Clonidine hydrochloride is a new antihypertensive agent with a primary site of action in the central nervous system. When administered with a diuretic, it is effective for long-term therapy and may be particularly useful in patients with moderately severe hypertension. Clonidine is comparable to methyldopa in efficacy but may cause side-effects more frequently. The only potentially serious adverse reaction that has been reported is a rebound increase in blood pressure that may occur following rapid withdrawal.

(JAMA 233:174-176, 1975)

Author Affiliations
Dr. Kosman is Senior Scientist, AMA Department of Drugs. This communication was prepared with the assistance of consultants.

Footnotes
Scientific data on clonidine hydrochloride were supplied by Boehringer Ingelheim Ltd., Elmsford, NY.

Reprint requests to Department of Drugs, American Medical Association, 535 N Dearborn St, Chicago, IL 60610 (Dr. Kosman).

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