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Jay B. Brodsky, MD; George E. Burgess III, MD

JAMA. 1975;234(11):1156-1157.

Abstract
A patient with factor XI deficiency had pulmonary embolism, although his factor XI assay was less than 1% of normal and his postoperative course was complicated by prolonged bleeding. Programs designed to prevent postoperative venous thrombosis should be carried out in factor XI-deficient patients, since the deficient state offers no protection from a pulmonary embolus. All surgical patients who are to receive low-dose heparin therapy as a part of such a program should be screened by means of preoperative determination of the partial thromboplastin time, to identify previously unsuspected bleeding disorders.

(JAMA 234:1156-1157, 1975)

Author Affiliations
From the Department of Anaesthesia, Harvard Medical School at Beth Israel Hospital, Boston.

Footnotes
Reprint requests to Department of Anaesthesia, Beth Israel Hospital, 330 Brookline Ave, Boston, MA 02215 (Dr Brodsky).

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