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Preliminary Report of a New Approach to Local Immunotherapy With BCG

Stephen P. Richman, MD; Giora M. Mavligit, MD; Richard Wolk, MD; Jordan U. Gutterman, MD; Evan M. Hersh, MD

JAMA. 1975;234(12):1233-1235.

Abstract
Because of the serious toxicity of intralesionally injected BCG, including high fever, local ulceration, chronic drainage, and disseminated BCG disease, 13 patients received local BCG immunotherapy by the new approach of epilesional scarification. Three patients had complete responses, four had partial responses, and six had no response. Toxic reactions were minimal compared to those reported for intralesionally given BCG.

(JAMA 234:1233-1235, 1975)

Author Affiliations
From the Section of Immunology, Department of Developmental Therapeutics, University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston.

Footnotes
Reprint requests to Department of Developmental Therapeutics, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, 6723 Bertner Ave, Houston, TX 77025 (Dr Richman).

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