Phencyclidine. Nine cases of poisoning
C. B. Liden, F. H. Lovejoy Jr and C. E. Costello
In nine cases of phencyclidine hydrochloride poisoning, early signs of
overdose included drowsiness, nystagmus, miotic pupils, blood pressure
elevation, increased deep tendon reflexes, ataxia, anxiety, and agitation.
In more severe cases, seizures, spasticity, and opisthotonos were seen in
addition to deep coma and respiratory depression. Treatment included
removal by emetics or lavage, hydration, and a quiet, reassuring
environment. Spasticity, agitation, and ocular manifestions responded to
diazepam. Psychiatric intervention was instituted after the patients were
stable and no longer agitated.
