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Problems Associated With Rabies Preexposure Prophylaxis
Walton R. Garner, MD;
David O. Jones, DVM, MPH;
Elaine Pratt, RN
JAMA. 1976;235(11):1131-1132.
Abstract
With the rabies vaccine presently available for preexposure prophylaxis, 20% of all individuals do not have seroconversion following routine immunizations, and 5% are allergic to this vaccine. Two experimental rabies vaccines of cell culture origin offering greater purity and potency were evaluated by means of a double-blind experiment. Thirty-one volunteers who did not have seroconversion or who were allergic to duck embryo rabies vaccine received rabies vaccine produced in either human diploid cell culture (WI38), or hamster kidney-cell culture. All volunteers had seroconversion within 14 days of receiving a single injection of either experimental vaccine. Clinical side effects were only minor.
(JAMA 235:1131-1132, 1976)
Author Affiliations
From the Department of Preventive Medicine, Ohio State University Student Health Service (Dr Garner and Ms Pratt) and the Department of Veterinary Preventive Medicine, Ohio State University (Dr Jones), Columbus.
Footnotes
Reprint requests to Ohio State University Student Health Service, 1875 Millikin Rd, Columbus, OH 43210 (Dr Garner).
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