This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (44)  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

2. Applications

Milo Gibaldi, PhD; Gerhard Levy, PharmD

JAMA. 1976;235(18):1987-1992.

Abstract
The pharmacokinetic concepts introduced and defined in a preceding article are now applied to the management of drug therapy for the individual patient. The factors that affect the time course of drug concentrations in plasma produced by repetitive administration include the dosing rate, total clearance, biologic half-life, and systemic availability of the drug. A clinical pharmacokinetics service can monitor drug concentrations in biologic fluids, design individualized drug-dosing regimens, and carry out pharmacokinetic diagnostic work-ups to help determine the reasons for a patient's unusual response to drug therapy.

(JAMA 235:1987-1992, 1976)

Author Affiliations
From the Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Buffalo.

Footnotes
Reprint requests to Department of Pharmaceutics, School of Pharmacy, State University of New York, Buffalo, NY 14214 (Dr Gibaldi).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Drug Therapy in Renal Failure: Dosing Guidelines for Adults: Part I: Antimicrobial Agents, Analgesics
BENNETT et al.
ANN INTERN MED 1980;93:62-89.
ABSTRACT  

Guidelines for Drug Therapy in Renal Failure
BENNETT et al.
ANN INTERN MED 1977;86:754-783.
ABSTRACT